Ultra Market Research | T Cell Therapy Market
T Cell Therapy Market Insights - Trends, Growth, and Key Players.

T Cell Therapy Market

  • Report ID : 616

  • Category : Biotechnology

  • No Of Pages : 140

  • Published on: August 2024

  • Status: Published

  • Format : Power Point PDF Excel Word

Key Question Answer

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Global Market Outlook

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In-depth analysis of global and regional trends

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Analyze and identify the major players in the market, their market share, key developments, etc.

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To understand the capability of the major players based on products offered, financials, and strategies.

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Identify disrupting products, companies, and trends.

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To identify opportunities in the market.

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Analyze the regional penetration of players, products, and services in the market.

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Comparison of major players financial performance.

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Evaluate strategies adopted by major players.

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Recommendations

T Cell Therapy Market
With a compound annual growth rate (CAGR) of XX% from 2024 to 2033, the worldwide T cell therapy market is projected to reach approximately US$ XX billion by 2033 from its estimated US$ XX billion in 2023. CAR The market for T-cell therapy is expanding as a result of its safety benefits, which include a decreased requirement for harsh chemotherapy and immunosuppression, as well as its proven ability to induce remission even in patients with recurrent cancer, increasing overall survival and opening the door for potentially curative procedures like stem cell transplantation.
 

Market Overview
Market for T cell therapy is expanding quickly due to improvements in cancer treatment methods. With this kind of treatment, a patient's T cells are altered in a lab to specifically target and destroy cancer cells. This method, called chimeric antigen receptor (CAR) T-cell therapy, uses genetically modified T cells to recognize and destroy malignant cells. The procedure comprises removing T cells from the patient's blood, reintroducing them into the patient's circulation after genetically altering them to express particular receptors in the lab.
. Adoptive cell therapy is another name for this technique that is being researched for additional cancer types and shows promise in treating blood malignancies. In order to maximize the efficiency of the modified T cells, patients may get radiation therapy and chemotherapy during the 2 to 8 week T-cell transfer therapy procedure. In the end, this novel strategy seeks to strengthen the body's immune response to cancer, perhaps improving patient outcomes and treatment efficacy.
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Key Insights

•    North America captured highest the market share.
•    By therapy type, the CAR T-cell therapy segment generated highest market share.
•    By indication, the hematologic malignancies segment contributed highest revenue share.
•    By end user, the hospital segment is expected to grow at a significant rate over the forecast period.

 

Regional Stance
Market for CAR T-cell treatment is anticipated to peak in North America, with the US predicted to take the lead. CAR-T treatments may be available for about 3.9% of US patients with advanced or metastatic cancer, offering a sizable market opportunity. The American Society for Blood and Marrow Transplantation Pharmacy Special Interest Group performed a survey on CAR T-cell treatment practices in order to evaluate the infrastructure and procedures across the country.
CAR T-cell therapies have been approved by the FDA to treat certain lymphomas, leukemias, and multiple myeloma; these treatments are usually administered after other forms of treatment have failed. Though promising, CAR T-cell treatment is still difficult to administer; it needs specific knowledge and is only available in a few facilities in Ontario, Canada. Nonetheless, the National Research Council (NRC) is working to improve CAR T-cell therapies that are produced domestically, with an emphasis on patient accessibility and affordability.
With the highest projected Compound Annual expansion Rate (CAGR) during the forecast period, the Asia Pacific region is expected to witness substantial expansion in the CAR-T-cell treatment market. The Indian government has undertaken various measures to improve the country's healthcare system. One such program is the National Health Mission, which aims to increase access to medical equipment and encourage community involvement in healthcare decision-making.
To further improve access to healthcare, the Ayushman Bharat initiative also offers health insurance coverage for hospitalization in secondary and tertiary care. With only two therapies currently approved by the National Medical Products Administration (NMPA) for CAR-T-cell therapy—axicabtagene ciloleucel (Yescarta) and relmacabtagene autoleucel (Carteyva)—the clinical research landscape in China is changing. This indicates the region's potential for further market expansion and innovation in this field.

Report Highlights     
By Type        

Tumor Infiltrating Lymphocytes (TIL)-based therapy, T Cell Receptor (TCR)-based therapy, and CAR T-cell therapy comprise the segments of the worldwide T-cell therapy market. CAR T-cell therapy is anticipated to lead the market among these categories for the duration of the projection. Clinical trials have shown that CAR T-cell therapy is more effective than conventional treatments, especially when treating specific forms of blood cancer.
Using a lab-made gene, this novel technique modifies T-cells to make them capable of identifying and eliminating cancer cells. When standard therapies fail or cancer returns, medical professionals may choose to use CAR T-cell therapy.

 

By Indication
Based on indication, the global market for T-cell therapy is divided into solid tumors, hematologic malignancies, and other disorders. Of these, the hematologic malignancies category is expected to hold a substantial market share for the duration of the forecast. Receptor chimeric antigen T-cell immunotherapy, or CAR-T, makes use of the patient's own T cells that have been modified to express chimeric antigen receptors, which identify antigens linked to tumors and cause the tumor cells to die.
Hematologic malignancies have shown encouraging response to CAR-T treatment. Novel approaches to treating cancer have been made possible by recent developments in tumor immunology, namely immune-targeted treatments such as CAR-T cell therapy, antibody-drug conjugates, monoclonal antibodies, and bispecific antibodies. In particular, CAR-T cell therapy has transformed the treatment of hematologic malignancies, producing hitherto unseen outcomes in cases of multiple myeloma (MM), non-Hodgkin lymphoma (NHL), and relapsed/refractory (R/R) B-cell acute lymphocytic leukemia (B-ALL) in recent years.
Hospitals and cancer treatment facilities make up the end-user section of the global T-cell therapy market. Over the course of the forecast period, the hospital segment is expected to experience significant expansion. Due to its complexity and specialized nature, CAR T-cell therapy requires knowledge and resources that are predominantly found in hospital settings. After a few weeks, T cells are extracted and altered by specialists before being reinfused into the patient's circulation.
Usually, the procedure entails lymphodepletion, in which chemotherapeutic medications are used to lower the quantity of healthy T cells and make room for the injected CAR T cells. The process of injecting CAR T cells into a patient's circulation through an IV or central line usually takes less than 30 minutes at hospitals or specialist cancer treatment facilities.

Market Dynamics
Driver
Advancements in CAR T Cell Research
The market for T cell treatment is expanding due to developments in CAR T cell research, as additional antigens are being explored in clinical trials as possible targets for CAR T cells. Additional tumor antigens that are suitable for targeting by CAR T cells have been found by researchers, which has led to the creation of therapies that target numerous antigens at once. This development represents a major advancement in the treatment of cancer and is driving the market for T cell therapy to grow.
 

Restraints
Challenges in CAR T-cell Therapy Affordability and Access

Due to their complex manufacturing processes and expensive patient-specific production, CAR T-cell treatments confront numerous challenges. Even though cutting-edge techniques like allogeneic CAR T-cells have the potential to save costs, the current high costs—which frequently exceed $400,000 USD and occasionally surpass $1 million USD per patient—along with logistical challenges raise questions about accessibility for patients, payers, and healthcare systems around the world.
The production procedure, which includes leukapheresis, genetic engineering using viral vectors, and regulated T cell multiplication, significantly raises these costs and prevents the market for T cell treatment from growing.

Opportunities
CAR-T Immunotherapy for Solid Tumors
Treatment for leukemia and lymphoma has been transformed by CAR-T cell immunotherapy; yet, its potential to cure a wider range of malignancies, including solid tumors like HNSCCs, is still largely unrealized. Progress in solid tumor CAR-T therapy has been hampered by issues such tumor heterogeneity, a lack of tumor-specific antigens, and immunosuppressive microenvironments. But as CAR-T structural design continues to progress from first to fifth generation, there are encouraging prospects to get over these challenges and extend the use of CAR-T therapy to solid tumors, which will propel the market for T cell therapy.
 

Recent Development
•    In February 2024, Astellas and Kelonia Therapeutics entered into a Research and License Agreement to develop novel Immuno-Oncology Therapeutics 
 B-Cell lymphoma 
•    In January 2022, Immunocore announced FDA approval of KIMMTRAK (tebentafusp-tebn) for the treatment of unresectable or metastatic uveal melanoma 
•    In March 2023, Adaptimmune Therapeutics plc and TCR² Therapeutics Inc. announced entry into a definitive agreement under which Adaptimmune would combine with TCR² in an all-stock transaction to create a preeminent cell therapy company focused on treating solid tumors 
•    In April 2022, Yescarta received U.S. FDA approval as the first CAR T-cell therapy for the initial treatment of relapsed or refractory Large B-cell Lymphoma (LBCL) source: https://www.gilead.com/news-and-press/press-room/press-releases/2022/4/yescarta-receives-us-fda-approval-as-first-car-tcell-therapy-for-initial-treatment-of-relapsed-or-refractory-large-bcell-lymphoma-lbcl.
•    In January 2024, Adaptimmune announced U.S. FDA acceptance of Biologics License Application for Afami-cel for the treatment of advanced Synovial Sarcoma with Priority Review 

Key Players in the T Cell Therapy Market
•    Pfizer Inc.
•    Fate Therapeutics
•    Sorrento Therapeutics
•    TCR2 Therapeutics Inc
•    Bluebird Bio Inc.
•    Gilead Sciences Inc.
•    Merck KGaA
•    Novartis AG
•    Amgen
•    Celgene Corporation

 

Market Segmentation
By Therapy Type
CAR T-cell Therapy
T Cell Receptor (TCR)-based
Tumor Infiltrating Lymphocytes (TIL)-based
By Indication
 Hematologic Malignancie
Lymphoma
Leukemia
Myeloma
Solid Tumors
Melanoma
Brain & Central Nervous System
Liver Cancer
Others
By End User
Hospitals
Cancer Treatment Centers


By Geography
North America
U.S.
Canada
Europe
Germany
France
United Kingdom
Rest of Europe
Asia Pacific
China
Japan
 India
Southeast Asia
Rest of Asia Pacific
Latin America
Brazil
Rest of Latin America
Middle East & Africa (MEA)
GCC
North Africa
South Africa
Rest of Middle East & Africa

 


 

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