Ultra Market Research | United States Alzheimer’s Disease Market
United States Alzheimer’s Disease Market
Report ID : 996
Category : Pharmaceuticals,United-States(US)
No Of Pages : 89
Published on: February 2025
Status: Published
Format :
Key Question Answer
Global Market Outlook
In-depth analysis of global and regional trends
Analyze and identify the major players in the market, their market share, key developments, etc.
To understand the capability of the major players based on products offered, financials, and strategies.
Identify disrupting products, companies, and trends.
To identify opportunities in the market.
Analyze the regional penetration of players, products, and services in the market.
Comparison of major players financial performance.
Evaluate strategies adopted by major players.
Recommendations
United States Alzheimer’s Disease Market Introduction United States Alzheimer's Disease Market revolves around the management, diagnosis, and treatment of Alzheimer's disease, a progressive neurodegenerative condition that predominantly occurs in the elderly. Alzheimer's disease results in memory loss, cognitive impairment, and ultimately loss of independence. At present, more than 6.9 million Americans aged 65 and above have Alzheimer's disease, which is expected to swell to 13.8 million by 2060. The market is growing with the expanding research activity, novel therapeutic candidates, and advances in diagnostic methodologies. Recent developments point toward disease-modifying treatments (DMTs), and products that act against amyloid plaques and tau proteins are emerging as leading trends. Growth in biomarker-based diagnostics and AI-assisted early detection is also contributing significantly to redefining the market. In 2024, the United States Alzheimer's Disease Market stood at USD 3.1 billion, and it is expected to grow at a CAGR of 6.8% to reach around USD 6.3 billion by 2034.
Segmentation Therapeutic Approaches • Disease-Modifying Therapies (DMTs) o Amyloid-Targeting Agents Monoclonal Antibodies Lecanemab Donanemab Others Small Molecule Inhibitors BACE Inhibitors Gamma-Secretase Inhibitors Others o Tau Protein Modulators Anti-Tau Monoclonal Antibodies Tau Aggregation Inhibitors o Neuroinflammation Modulators Anti-Inflammatory Agents Microglial Modulators o Others • Symptomatic Treatments o Cognitive Enhancers Cholinesterase Inhibitors (Donepezil, Rivastigmine) NMDA Receptor Antagonists (Memantine) Others o Neuropsychiatric Symptom Treatments Antidepressants Antipsychotics o Adjunctive Therapies Nutritional Supplements Lifestyle Interventions o Others
Diagnostic Tools • Imaging Techniques o Positron Emission Tomography (PET) Amyloid PET Imaging Tau PET Imaging o Magnetic Resonance Imaging (MRI) Structural MRI Functional MRI o Others • Biomarker Assays o Cerebrospinal Fluid (CSF) Biomarkers Amyloid Beta Levels Tau Protein Levels o Blood-Based Biomarkers Plasma Amyloid Beta Neurofilament Light Chain (NfL) o Others • Genetic Testing o APOE Genotyping o Familial Alzheimer's Gene Panels o Others
List of Market Players 1. Biogen Inc. (USA) 2. Eli Lilly and Company (USA) 3. Eisai Co., Ltd. (Japan) 4. Roche Holding AG (Switzerland) 5. Novartis International AG (Switzerland) 6. Pfizer Inc. (USA) 7. Merck & Co., Inc. (USA) 8. Johnson & Johnson (USA) 9. AbbVie Inc. (USA) 10. AstraZeneca plc (UK) 11. Amgen Inc. (USA) 12. GlaxoSmithKline plc (UK) 13. Sanofi S.A. (France) 14. Takeda Pharmaceutical Company Limited (Japan) 15. Cassava Sciences, Inc. (USA)
Drivers United States Alzheimer's Disease Market is spurred by a growing population, and more cases of Alzheimer's disease necessitate novel treatment options. Early detection and diagnosis have enhanced with the progress in imaging modalities and blood tests based on biomarkers, enabling earlier treatment. The advent of disease-modifying therapies (DMTs) like Lecanemab and Donanemab is a breakthrough, with agencies like the FDA granting approvals in record time. Public-private collaborations and government grants have driven Alzheimer's research faster, and innovation has increased. AI-based cognitive assessment devices and wearable devices assist in monitoring disease progression, enhancing patient monitoring.
Restraints Despite encouraging advancements, the United States Alzheimer's Disease Market is challenged. Low clinical trial success rates and high drug development costs slow down the pipeline for new drugs. Numerous Alzheimer's drugs have flopped in late-stage trials, causing massive financial losses for drug firms. High expense of new drugs, like Lecanemab ($26,500 per year), reduces access, particularly among uninsured and disadvantaged patients. Also, the diagnostic limitations and misdiagnosis problems persist, as Alzheimer's symptoms can mimic those of other neurodegenerative diseases. Distrust by the public regarding new therapies and concerns related to safety from side effects also curb the rate of adoption.
Opportunities United States Alzheimer's Disease Market offers great potential with the increasing trend of precision medicine. Treatments personalized for genetic and biomarker profiles might enhance the efficacy of therapy. Moreover, growing adoption of digital health technologies such as mobile applications and remote cognitive testing platforms is improving early detection. Biopharma firms are pouring money into alternative mechanisms of action for drugs, including anti-tau treatments and anti-inflammatory methods. Partnerships among pharma firms, research institutes, and universities are growing, promoting drug development at an accelerated rate. In addition, the move toward non-invasive diagnostics, like blood-based biomarkers, presents a cost-saving means of enhancing early detection and intervention.
Trends The US Alzheimer's Market is experiencing a number of revolutionizing trends that are transforming diagnostics, treatment, and patient care. Perhaps the most important trend is the evolution in AI-driven diagnostics, wherein machine learning algorithms decipher brain scans and cognitive test data to identify early signs of Alzheimer's with increased precision and accuracy. Biomarker diagnostics based on blood are also becoming increasingly popular as a less invasive and cheaper option compared to cerebrospinal fluid (CSF) examination and PET scanning, facilitating broader application for the early detection of disease. Another trend is combination therapies, which are targeting several pathways in Alzheimer's pathology, including amyloid-beta, tau protein, and neuroinflammation. Gene therapy research is also gaining pace, with therapeutic trials investigating CRISPR-mediated genetic editing to modify disease pathology at the molecular level. Further, the incorporation of wearable technology and remote cognitive assessment tools is transforming patient monitoring by monitoring cognitive function, sleep, and vital signs in real-time. All these trends are together contributing to enhanced early detection, customized treatment strategies, and better patient outcomes in the Alzheimer's disease market.
As of 2024, the market is valued at USD 3.1 billion and is expected to grow at a CAGR of 6.8%.
Major players include Biogen, Eli Lilly, Roche, Eisai, Pfizer, and Novartis.
Lecanemab and Donanemab were recently approved as disease-modifying therapies.
High drug costs, clinical trial failures, and limited access to advanced diagnostics remain major challenges.
AI-based brain scans, cognitive tests, and wearable health tracking are improving early detection and monitoring.
1. Introduction 1.1 Report Description 1.2 Research Methodology 1.2.1 Data Mining 1.2.2 Market Modeling and Forecasting 1.2.3 Data Validation 1.2.4 Industry Analysis
2. Market Dashboard
3. Market Overview 3.1 Market Definition and Scope 3.2 Market Segmentation 3.2.1 By Treatment Types • Disease-Modifying Therapies (DMTs) o Amyloid-Targeting Agents Monoclonal Antibodies Small Molecule Inhibitors Others o Tau Protein Modulators Anti-Tau Monoclonal Antibodies Tau Aggregation Inhibitors o Neuroinflammation Modulators Anti-Inflammatory Agents Microglial Modulators o Others • Symptomatic Treatments o Cognitive Enhancers Cholinesterase Inhibitors NMDA Receptor Antagonists o Neuropsychiatric Symptom Treatments Antidepressants Antipsychotics o Adjunctive Therapies Nutritional Supplements Lifestyle Interventions o Others 3.2.2 By Patient Demographics • Elderly Patients (65+ years) • Early-Onset Alzheimer’s (Under 65 years) • Genetic Risk Group 3.2.3 By Diagnostic Tools • Imaging Techniques o Positron Emission Tomography (PET) Amyloid PET Imaging Tau PET Imaging o Magnetic Resonance Imaging (MRI) Structural MRI Functional MRI o Others • Biomarker Assays o Cerebrospinal Fluid (CSF) Biomarkers o Blood-Based Biomarkers o Others • Genetic Testing o APOE Genotyping o Familial Alzheimer’s Gene Panels o Others 3.2.4 By Distribution Channels • Hospitals & Clinics o Neurology Clinics o Memory Care Centers • Retail Pharmacies o Chain Pharmacies o Independent Pharmacies • Online Pharmacies 3.2.5 By Therapeutic Applications • First-Line Treatment o Cholinesterase Inhibitors o NMDA Receptor Antagonists o Lifestyle-Based Interventions • Disease Progression Treatment o Monoclonal Antibodies o Combination Therapies • Refractory Alzheimer’s Disease o Experimental Therapies o Adjunctive Symptom Management 3.3 Market Dynamics 3.3.1 Drivers 3.3.2 Restraints 3.3.3 Opportunities 3.3.4 Challenges
4. United States Alzheimer’s Disease Market by Treatment Types 4.1 Introduction 4.2 Market Size and Growth Rate by Treatment Types (2024-2030) 4.2.1 Disease-Modifying Therapies • Amyloid-Targeting Agents • Tau Protein Modulators • Neuroinflammation Modulators 4.2.2 Symptomatic Treatments • Cognitive Enhancers • Neuropsychiatric Symptom Treatments • Adjunctive Therapies
5. United States Alzheimer’s Disease Market by Patient Demographics 5.1 Introduction 5.2 Market Size and Growth Rate by Patient Demographics (2024-2030) 5.2.1 Elderly Patients (65+ years) 5.2.2 Early-Onset Alzheimer’s (Under 65 years) 5.2.3 Genetic Risk Group
6. United States Alzheimer’s Disease Market by Diagnostic Tools 6.1 Introduction 6.2 Market Size and Growth Rate by Diagnostic Tools (2024-2030) 6.2.1 Imaging Techniques 6.2.2 Biomarker Assays 6.2.3 Genetic Testing
7. United States Alzheimer’s Disease Market by Distribution Channels 7.1 Introduction 7.2 Market Size and Growth Rate by Distribution Channels (2024-2030) 7.2.1 Hospitals & Clinics 7.2.2 Retail Pharmacies 7.2.3 Online Pharmacies
8. United States Alzheimer’s Disease Market by Therapeutic Applications 8.1 Introduction 8.2 Market Size and Growth Rate by Therapeutic Applications (2024-2030) 8.2.1 First-Line Treatment 8.2.2 Disease Progression Treatment 8.2.3 Refractory Alzheimer’s Disease
9. Competitive Landscape 9.1 Company Profiles 9.1.1 Biogen Inc. (United States) • Business Overview • Product Portfolio • Strategic Developments • Financial Overview 9.1.2 Eli Lilly and Company (United States) 9.1.3 Eisai Co., Ltd. (Japan) 9.1.4 Roche Holding AG (Switzerland) 9.1.5 Novartis International AG (Switzerland) 9.1.6 Pfizer Inc. (United States) 9.1.7 Merck & Co., Inc. (United States) 9.1.8 Johnson & Johnson (United States) 9.1.9 AbbVie Inc. (United States) 9.1.10 AstraZeneca plc (United Kingdom) 9.1.11 Amgen Inc. (United States) 9.1.12 GlaxoSmithKline plc (United Kingdom) 9.1.13 Sanofi S.A. (France) 9.1.14 Takeda Pharmaceutical Company Limited (Japan) 9.1.15 Cassava Sciences, Inc. (United States)
10. Conclusion and Recommendations
11. Appendix 11.1 List of Tables • Market Size of United States Alzheimer’s Disease Market (2024–2030) • Segmentation Breakdown of United States Alzheimer’s Disease Market • List of Approved and Pipeline Alzheimer’s Drugs • Key Market Players and Their Market Share • Distribution Channels and Revenue Contribution
11.2 List of Figures • Alzheimer’s Disease Market Size and Forecast (2024–2030) • Market Segmentation by Treatment Type • Growth Trends in Disease-Modifying Therapies • Market Share of Leading Pharmaceutical Companies • Adoption Rate of Diagnostic Technologies
Research Methodology
The process of market research at Ultra Market Research is an iterative in application and usually follows following path. Information from secondary used to build data models, then results from data models are validated from primary participants. Then cycle repeats where, according to inputs from primary participants, additional secondary research is done, and new Information is again incorporated into data model. The process continues till desired level of Information is not generated
To calculate the market size, the report considers the revenue generated from the sales of Ultra Market Research providers. The revenue generated from the sales of Ultra Market Research has been calculated through primary and secondary research. The report also presents the key players operating in the Ultra Market Research market across the globe identified through secondary research and a corresponding detailed analysis of the top vendors in the market. The market size calculation also includes distribution channel segmentation determined using secondary sources and verified through primary sources.
Secondary Research
The secondary research source that are typically referred to include, but are not limited to:
Company websites, annual reports, financial reports, broker reports, investor presentations and SEC filings
Internal and external proprietary databases, relevant patent and regulatory databases
National government documents, statistical databases and market reports
News articles, press releases and web-casts specific to the companies operating in the market
The source for secondary research includes but is not limited to: Factiva, Hoovers and Statista
Inner Circle Represents – Stage of Research Process
Middle Circle Represents – Source of Information
Outer Circle Represents – Information Derived from that source
Primary Research We conduct primary interviews on an ongoing basis with industry participants and commentators in order to validate data and analysis. A typical research interview fulfills the following functions:
It provides first-hand Information on the market size, market trends, growth trends, competitive landscape, future outlook etc.
Helps in validating and strengthening the secondary research findings
Further develops the analysis team’s expertise and market understanding
Primary research involves E-mail interactions, telephonic interviews as well as face-to-face interviews for each market, category, segment and sub-segment across geographies
The participants who typically take part in such a process include, but are not limited to:
Industry participants: CEOs, VPs, marketing/ distribution channel managers, market intelligence managers and national sales managers
Purchasing managers, technical personnel, distributors and resellers
Outside experts: Investment bankers, valuation experts, research analysts specializing in specific markets
Key opinion leaders specializing in different areas corresponding to different industry distribution channels
Models Where no hard data is available, we use modeling and estimates in order to produce comprehensive data sets. A rigorous methodology is adopted in which the available hard data is cross referenced with the following data distribution channels to produce estimates:
Demographic data: Population split by segment
Macro-economic indicators: GDP, etc.
Industry indicators: Expenditure, distribution channel stage & infrastructure, sector growth and facilities.
Data is then cross checked by the expert panel.
2..1 Company Share Analysis Model
Company share analysis is used to derive the size of United States market. As well as study of revenues of companies for last three to five years also provide the base for forecasting the market size and its growth rate. This model is built in following steps: 2..2 Revenue Based Modeling
Revenue based models can be built in two ways – Top-Down or Bottom-Up irrespective of industry. Market size estimated from company share analysis acts as a validation point for bottom-up approach where as it acts as starting point for top-down approach.
2.1 Research Limitations Inflation is not a part of pricing in this report. Prices of United States Alzheimer’s Disease Market and its derivatives vary in each region and hence similar revenue ratio does not follow for each individual region. The same price for each distribution channel has been taken into account while estimating and forecasting market revenue Globally. Regional average price has been considered while breaking down this market by application in each region. This report provides market size of United States Alzheimer’s Disease Market for the past year and forecasts for the next six years. United States Alzheimer’s Disease Market size is given in terms of revenue Market revenue is defined in USD Million. Market numbers are given on the basis of different United States Alzheimer’s Disease Market categories. Market size and forecasts for each major application is provided in the context of Global market. The numbers provided in this report are derived on the basis of demand for United States Alzheimer’s Disease Market from different application industries in different regions.
Segmentation Therapeutic Approaches • Disease-Modifying Therapies (DMTs) o Amyloid-Targeting Agents Monoclonal Antibodies Lecanemab Donanemab Others Small Molecule Inhibitors BACE Inhibitors Gamma-Secretase Inhibitors Others o Tau Protein Modulators Anti-Tau Monoclonal Antibodies Tau Aggregation Inhibitors o Neuroinflammation Modulators Anti-Inflammatory Agents Microglial Modulators o Others • Symptomatic Treatments o Cognitive Enhancers Cholinesterase Inhibitors (Donepezil, Rivastigmine) NMDA Receptor Antagonists (Memantine) Others o Neuropsychiatric Symptom Treatments Antidepressants Antipsychotics o Adjunctive Therapies Nutritional Supplements Lifestyle Interventions o Others
Diagnostic Tools • Imaging Techniques o Positron Emission Tomography (PET) Amyloid PET Imaging Tau PET Imaging o Magnetic Resonance Imaging (MRI) Structural MRI Functional MRI o Others • Biomarker Assays o Cerebrospinal Fluid (CSF) Biomarkers Amyloid Beta Levels Tau Protein Levels o Blood-Based Biomarkers Plasma Amyloid Beta Neurofilament Light Chain (NfL) o Others • Genetic Testing o APOE Genotyping o Familial Alzheimer's Gene Panels o Others