Ultra Market Research | Automated and Closed Cell Therapy Market
Automated and Closed Cell Therapy Market - Innovations and Growth Potential

Automated and Closed Cell Therapy Market

  • Report ID : 587

  • Category : Pharmaceuticals

  • No Of Pages : 150

  • Published on: July 2024

  • Status: Published

  • Format : Power Point PDF Excel Word

Key Question Answer

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Global Market Outlook

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In-depth analysis of global and regional trends

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Analyze and identify the major players in the market, their market share, key developments, etc.

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To understand the capability of the major players based on products offered, financials, and strategies.

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Identify disrupting products, companies, and trends.

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To identify opportunities in the market.

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Analyze the regional penetration of players, products, and services in the market.

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Comparison of major players financial performance.

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Evaluate strategies adopted by major players.

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Recommendations

Automated and Closed Cell Therapy Market


With a compound annual growth rate (CAGR) of XX% from 2024 to 2033, the global market for automated and closed cell therapy is projected to reach approximately US$ XX billion by 2033 from its estimated US$ XX billion in 2023. The cell treatment sector is experiencing notable expansion due to the implementation of closed manufacturing processes. The reduction of change-over processes and the facilitation of various product manufacturing in parallel lead to cost savings and improved product quality. Closed systems reduce the possibility of contamination, especially in cleanrooms with lower classifications. Processes are further streamlined by automation, which raises quality, lowers complexity, and increases safety. Because of this, the market for closed and automated cell treatment is growing significantly.


Market Overview
Market for automated and closed cell treatment is expanding quickly due to the growing number of autologous cell therapy devices that are passing FDA approval and clinical trial stages. a vital need for proven cell manufacturing technologies that can grow from development to commercialisation and scale throughout production stages. In cleanrooms and biosafety cabinets, skilled workers perform labour-intensive procedures, particularly in the early stages of cell manufacture when open culture tanks are used. This environment is being revolutionised by automated closed systemsThese technologies improve manufacturing processes' repeatability and dependability while adhering to the current Good Manufacturing Practice (cGMP) framework's Quality by Design (QbD) principles. By increasing automation, these systems reduce costs by minimising hands-on operator time, facilitating the manufacture of many items in parallel, and streamlining technology transfer procedures. They also increase product quality and reproducibility.
•    In April 2024, Multiply Labs and GenScript Biotech Corporation joined forces to automate the Cell Isolation and Enrichment Phase of Cell Therapy Manufacturing.
 

Key Insights

•    North America generated largest revenue share in.
•    By workflow, the expansion segment dominates the market and captures largest of the revenue share. 
•    By workflow, the apheresis segment is projected to witness remarkable growth.
•    By type, the non-stem cell therapy segment dominates the market and generated largest revenue share.
•    By scale, The Research and development (R&D) scale segment captured largest revenue share.
•    By scale, the commercial scale segment is expected to register remarkable growth.

 

Regional Stance
North America is clearly dominant in the automated and closed cell therapy processing systems market, as evidenced by its sizeable market share. It is anticipated that this tendency will continue as long as North America is dedicated to supporting innovation and developing talent in the technology industry. This leadership position is a result of programs that assist scientists in their early careers and offer technical workforce training, including graduate and undergraduate students, postdoctoral researchers, and academic faculty. Offering training programs to people from under-represented backgrounds in the scientific and technology industries, the US is diversifying its technical workforce. These initiatives strengthen the labour force as well as the country's advantage in biotechnology and biomanufacturing. An industrial revolution might be sparked by the rapidly developing field of biological technology, which would transform a number of sectors including fashion, materials, energy, and construction. As these cutting-edge biological technologies develop further, they will radically alter our physical environment and provide creative solutions in a variety of fields.
Over the course of the projection period, it is expected that the automated and closed cell therapy processing systems market in the United Kingdom would develop significantly. The National Health Service (NHS) is a major player in the United Kingdom's sixth-largest pharmaceutical sector in the world, holding over 98% of the market for prescription drugs. About 35,000 general practitioners (GPs) functioning in an atmosphere of free markets where top foreign pharmaceutical companies have strongholds are the main drivers of the market. The pharmaceutical industry continues to be one of the fastest-growing segments of NHS spending, despite a slowing growth rate. The UK government has put in place a number of measures to efficiently manage the cost of medications, such as offering financial incentives and placing restrictions on general practitioners' (GPs) ability to purchase medications. 
Market for automated and closed cell therapy processing systems is expected to grow significantly in the Asia Pacific area over the course of the projected period. From industrialised countries like Japan, South Korea, Taiwan, Singapore, and Australia to growing economies like Thailand, Indonesia, Malaysia, Vietnam, Bangladesh, the Philippines, China, and India, the area has a diversified demographic landscape. In order to keep up with industry trends, the pharmaceutical sector in the Asia Pacific area is fast changing, embracing innovation, adjusting to new technology, and going through a digital transformation. The goal of this strategy change is to guarantee the sustainability of patient care initiatives and programs. The region offers numerous prospects for expansion and advancement in the automated and closed cell therapy processing systems industry, owing to its strong economic indicators. Asia Pacific is positioned as a major actor in fostering innovation and the widespread implementation of automated cell therapy processing systems in the area as it continues to embrace technological breakthroughs in healthcare and prioritise patient care.


The automated and closed cell therapy processing systems market in Latin America, the Middle East, and Africa is experiencing steady growth, primarily driven by advancements in therapeutics platforms and systems development. In Latin America, pharmaceutical products have played a crucial role in enhancing life expectancy and improving overall quality of life. In the region, pharmaceutical innovations, combined with improved living standards and enhanced public health interventions, have significantly contributed to extending life expectancy and enhancing population well-being, particularly in Latin America and the Caribbean. As a result, there is increasing momentum in the adoption of automated and closed cell therapy processing systems to further enhance the efficiency and effectiveness of pharmaceutical manufacturing and therapeutics delivery across Latin America, the Middle East, and Africa. This steady growth trajectory underscores the growing importance of advanced technology in advancing healthcare outcomes and addressing the evolving healthcare needs of these regions.

Report Highlights     
By Workflow 
Expansion sector leads the market and generates the greatest percentage of revenue. This dominance derives from a move towards closed, automated systems across a range of medication manufacturing procedures within the pharmaceutical sector and regulatory agencies. There are several benefits to using closed, automated systems, chief among them being improved safety protocols. There is less chance of contamination, which lowers the possibility of batch loss or patient injury. Adopting this technology has shown to have observable advantages, including quicker approval procedures, energy efficiency, staffing reductions, and space optimisation. Cell culture production is a crucial step in drug manufacturing workflows where patient cells are grown and multiplied in well regulated environments. This crucial stage emphasises how crucial it is to use closed, automated systems to guarantee accuracy, reliability, and security in the manufacturing processes for cell therapy.
The apheresis market is expected to increase significantly during the course of the projection. Although cell therapy is a new and promising method, more work needs to be done to ensure that it is both cost-efficient and effective before its full therapeutic potential can be realised. Early cell treatments are produced through a labour-intensive procedure with several touchpoints. This labour-intensive process frequently results in inconsistent results, a danger of contamination, and longer throughput times. These difficulties eventually impede wider patient access and restrict the full potential of cell therapy by raising safety concerns and failure mechanisms. It is imperative that the apheresis section advances. Shorter throughput times, lower contamination hazards, and more efficiency can result from streamlining and optimising the apheresis process. By addressing these issues, the sector can endeavour to increase the affordability, accessibility, and efficacious, thereby expanding their reach to wider patient populations.

By Type
Market for closed-loop automated and automated cell treatment processing systems is dominated by non-stem cell therapy. Somatic cells from the human body are the main source of cells used in non-stem cell therapies. Before being given to patients for treatment, prevention, or as part of a diagnostic process, these cells are isolated, multiplied, and expanded. Non-stem cell therapies perform a variety of tasks, including providing growth factors, cytokines, and enzymes in vivo. They are also essential in the treatment of tumours through adoptive cell therapy (ACT), in the treatment of metabolic diseases by cell transplantation, and in the management of open wound injuries like burns or lesions as scaffolding cellsThe methods used to isolate and multiply these cells differ based on the kind of cell, where it is located in the body, and the planned use for therapeutic purposes. The non-stem cell treatment market seeks to maximise production process accuracy, efficiency, and safety by utilising closed and automated cell therapy processing systems. This will ultimately improve patient outcomes and broaden the application of these therapeutic modalities.

By End User
Global market for automated and closed cell therapy processing systems is dominated by the Research and Development (R&D) scale segment. The emphasis is on using closed-loop and automated manufacturing to solve the problems that currently exist in the production of cellular therapy products. With its new approach to treating underlying problems, including incurable diseases, regenerative medicine has great potential. Regenerative medicine is the source of automated cell culture technology, which runs in a closed system. Stakeholders hope to stimulate innovation, streamline production procedures, and clear the path for the broad implementation of closed-loop and automated cell therapy processing systems in the medical field by focussing on the R&D scale sector.


Market Dynamics
Driver
The Role of Closed Systems in Advancing Cell Therapy Manufacturing
With its wide range of therapeutic alternatives, cell and gene therapies are a promising new frontier in the treatment of disease. The development of cell and gene therapy manufacturing becomes critical as the demand for these cutting-edge treatments keeps growing. When compared to protein-based biologics, the manufacturing process for cell and gene therapy is noticeably more intricate and labour-intensive, even at lower volume operations. The procedure entails a number of complex procedures, such as washing, concentration, and cell separation. It is essential to carry out these tasks in a straightforward, safe, and effective manner in order to guarantee the effective manufacturing of cell treatments. Closed systems offer the highest levels of containment and product safety protection, making them a crucial solution for both clinical and commercial cell therapy operations. The automated and closed cell therapy market is growing due to the development of closed systems, which allows for efficient and dependable manufacturing processes that satisfy the industry's growing demands.
•    In March 2024, Cellares launched its Good Manufacturing Practice–compliant Cell Shuttle Manufacturing Platform, aiming to revolutionize cell therapy manufacturing.
•    In October 2022, Thermo Fisher Scientific introduced a Closed and Automated Cell Isolation and Bead Removal Solution, marking a significant advancement in cell therapy manufacturing.


Cost Challenges in CAR T-Cell Therapy Market
Despite the incredible effectiveness of Chimeric Antigen Receptor (CAR) T-cell therapy in treating a range of haematologic cancers, the high cost of this treatment prevents many countries from adopting it. As a result of the growing number of new cellular therapies and the increasing use of CAR T-cells in haematologic malignancies and other indications, creative ways to reduce therapy costs and create long-term payment structures are urgently needed. The market for automated and closed cell therapy is significantly hindered by the high cost of CAR T-cell therapy, which calls for deliberate initiatives to solve affordability issues and promote broader acceptance of these ground-breaking therapies.

Opportunities
Advancements in Cell Selection and Separation Techniques

Automation and advances in clinical and medical technology thrive when they have a direct influence on patient welfare. With the FDA's recent approval of chimeric antigen receptor (CAR) T-cell therapies and the use of T-cell and other cell-based therapies expanding beyond cancer, the topic of how to better harvest, culture, process, and modify therapeutic cells has come back into the spotlight. The development of methods for identifying and sorting cells with the greatest therapeutic potential from complicated mixtures present in drawn blood and expanded cultures is one important technological field that has the potential to streamline processes and lower costs connected with cell therapy. The automated and closed cell treatment market has a great chance to improve efficiency, precision, and cost thanks to this technical innovation, which will ultimately spur growth and make these revolutionary medicines more widely used.
•    In June 2022, Galapagos acquired CellPoint and AboundBio to accelerate access to next-generation cell therapies.
 

Recent Developments

•    In April 2024, Bristol Myers Squibb and Cellares announced a $380M Worldwide Capacity Reservation and Supply Agreement, aimed at accelerating the manufacture of CAR T Cell Therapies.
•    In February 2024, BioNTech and Autolus disclosed a Strategic CAR-T Cell Therapy Collaboration, aiming to advance their pipeline and expand late-stage programs.
•    In August 2023, Cellares collaborated with Bristol Myers Squibb to explore automated CAR-T cell therapy manufacturing.
•    In February 2024, Thermo Fisher expanded its partnership with Multiply Labs to automate cell therapy production.
•    In October 2023, CTMC partnered with ScaleReady to address manufacturing barriers in the industry.
 

Key Players in the Automated And Closed Cell Therapy Market
Lonza
BioSpherix
Cellares
Sortorius
Cytiva
ThermoGenesis Holdings Inc
Thermo Fisher Scientific Inc


Market Segmentation
By Workflow
Cryopreservation
Fill-finish
Separation
Expansion
Apheresis
Others 
By Type
Stem Cell Therapy
Non-stem Cell Therapy
By Scale
Commercial Scale
R&D Scale

By Geography
North America
U.S.
Canada
Europe
Germany
France
United Kingdom
Rest of Europe
Asia Pacific
China
Japan
India
 Southeast Asia
Rest of Asia Pacific
Latin America
Brazil
Rest of Latin America
Middle East & Africa (MEA)
GCC
North Africa
South Africa
Rest of Middle East & Africa

 

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