U.S. Biopreservation Market
Estimated at US$ XX billion in 2023, the U.S. biopreservation market is projected to reach around US$ XX billion by 2033, with a compound annual growth rate (CAGR) of XX% from 2024 to 2033. The Modern food preservation techniques are replacing traditional ones in the United States because they prevent nutrient loss and alter food status. This ensures food safety and quality. In today's worldwide food market, characterized by the introduction of new foods, technological advancements, and customer desire for minimally processed products with ready-to-eat quality and prolonged shelf life, this shift is especially pertinent.
Emerging as a dependable solution, bio-preservation provides advantages from farm to fork in the food supply chain. Biopreservation techniques fulfill industry regulations and growing consumer expectations while addressing the expansion of the U.S. biopreservation market by enhancing shelf life while preserving quality, sanitation, and low nutritional losses.
 

Market Overview
Use of bio-preservation techniques, which use natural or controlled microbiota and antimicrobials to increase food shelf life, is driving the rapid expansion of the U.S. biopreservation business. These methods work by controlling spoilage and deactivating pathogens by the use of fermentation products and beneficial bacteria, specifically lactic acid bacteria (LAB) and their metabolites. LAB, which are well-known for their antibacterial qualities, generate important substances such hydrogen peroxide, organic acids, and bacteriocins.
Peptides or proteins having antibacterial action known as bacteriocins are categorized into four groups according to their size, structure, and post-translational modification. LAB bacteriocins—most notably nisin—are highly valued for their broad bactericidal action, non-immunogenic, thermo-resistant properties, and non-toxicity, which makes them excellent bio-preservative agents. The vegetable, dairy, and meat sectors use nisin and other bacteriocins extensively; nisin has FDA approval. Endolysins and bacteriophages exhibit potential in the processing, preservation, and security of food. Particularly well-suited for DNA shuffles and protein engineering are bacteriocins and endolysins, which allow for the production of extremely powerful variations with broadened activity spectrum. The growing use of bacteriophages, endolysins, and LAB metabolites highlights the substantial growth potential of the U.S. biopreservation business, which is being propelled by improvements in food safety, quality, and preservation methods.

Report Highlights     
By Application
Biobanking is the most common use of biopreservation, accounting for a significant portion of the industry. These storage facilities are essential for the management and archiving of biological samples, or biosamples, which are needed for scientific investigations. Notably, biobanks have been essential to projects like the Cancer Genome Atlas (TCGA), which analyzes significant genetic abnormalities linked to cancer in order to compile a complete inventory of cancer genomic profiles. Large-scale genome sequencing allows researchers to study cohorts of more than 30 cancers by utilizing human specimens with related clinical data. Thanks to this method, new molecular changes in cancer have been found, making it possible to categorize tumor subtypes according to their unique genetic profiles.
By customizing therapies based on each patient's unique genetic traits, precision medicine has completely changed patient care. Therefore, the biobanking industry's importance in the biopreservation sector highlights its critical role in advancing medical research and tailored healthcare solutions.
Over the course of the forecast period, the segment focused on regenerative medicine is expected to develop at the fastest compound annual growth rate (CAGR). The practice of replacing or regenerating human cells, tissues, or organs in order to restore normal function is known as regenerative medicine. This field has enormous potential for replacing damaged tissues and organs directly or promoting the body's own healing processes. Through the use of regenerative medicine, tissues and organs can be grown in lab environments and safely transplanted when the body's natural healing processes are insufficient.
Regenerative medicine holds considerable promise for improving healthcare, with about one in three Americans possibly benefiting from it. With uses in stem cell therapy (injecting stem cells or progenitor cells), immunomodulation therapy (using biologically active molecules), and tissue engineering (planting lab-grown organs and tissues), stem cells are essential to regenerative medicine. All things considered, the quick development of regenerative medicine highlights its potential to transform clinical treatments and meet unmet medical needs.
 

By Product
The market share of biopreservation equipment is dominated by its vital function in preserving the quality and safety of items that are biopreserved. Employing biopreservation techniques is a calculated move to guarantee the creation of premium products that satisfy consumer needs. Although amplicon sequencing-based genomic methods are useful for characterizing food microbial populations, their application to biopreserved goods may present some challenges. Usually, bioprotective cultures are heavily inoculated, taking over the product's microbiome, especially when storage is first initiated. This dominance highlights its relevance in the biopreservation market environment and emphasizes how crucial efficient biopreservation equipment is to preserving product integrity during storage and delivery.
Market for biopreservation medium is expected to expand at the quickest compound annual growth rate (CAGR), and it is expected to play a key role in the overall market expansion. The use of biopreservation media is essential to guaranteeing the success of preservation initiatives. The kind of biological material being kept, the length of time that is wanted for storage, and the goal of the biopreservation process all play a role in choosing the right kind of media. The best biopreservation medium should support healthy cell recovery, preserve cell viability, and guarantee that post-preservation and thawing procedures do not impair functionality. Therefore, it is anticipated that the market for biopreservation as a whole will develop due to the steady increase in demand for premium biopreservation medium.
 

Market Dynamics
Driver 
Expanding Role Food Safety and Quality 
Utilizing the antibacterial properties of naturally existing organisms and their metabolites, bio-preservation provides a calculated method to satisfy contemporary demands for food safety and quality while also harmonizing safety requirements. The food industry relies heavily on techniques that use biological antimicrobial systems, such as lactic acid bacteria (LAB), bacteriocins, bacteriophages, and endolysins, to preserve the texture, flavor, and safety of its food items. These bio-preservatives are essential to the processing and preservation of food and present a viable way to improve food safety. Particularly bacteriocins and endolysins lend themselves well to DNA rearranging and protein engineering, which can provide extremely powerful variations with broadened activity spectrum.
Use of modified atmosphere packaging (MAP) in conjunction with the addition of bacteriocins to packaging films offers creative ways to increase shelf life and guarantee food safety. Although genetically engineered bacteriophages have potential for biopreservation, their widespread use as biopreservative agents will depend on how safety issues are resolved. The U.S. biopreservation market is expanding due to the food industry's growing use of bio-preservation procedures.

Restraints 
Functional Limitations of Bacteriocins 
Despite their potential for food preservation, bacteriocins have important functional constraints that prevent them from being used widely. Among these drawbacks are their generally limited range of inhibitory activity, which usually only targets particular microbes and frequently has no impact against gram-negative bacteria. When bacteriacins come into contact with dietary ingredients, their stability is weakened, which can result in a loss of function due to association with proteins and lipids or destruction by proteolytic enzymes. Because of these functional limitations, bacteriocins' efficacy as natural preservatives is compromised, which in turn limits the market's potential for expansion in the United States.
 

Opportunities
Growing Demand for Natural Food Preservatives 
Nutritional value of their diet and the possible negative health impacts of chemical additives in food are concerns that modern consumers are becoming more and more aware of. This has led to an increased emphasis on natural, fresh meals free of chemical preservatives. Finding safe and efficient natural preservatives, like bacteriocins, that can suppress or eliminate unwanted bacteria in food and improve food safety and shelf life, has become more interesting as a result of this trend. The move toward natural preservatives offers the American biopreservation industry a huge chance to adapt to changing consumer demands and take advantage of the rising desire for safer, healthier food options.

Recent Developments

   •    In January 2022, Thermo Fisher Scientific completed the acquisition of PeproTech, a leader in recombinant proteins. 
•    In September 2023, Merck became the first CTDMO to offer fully integrated services for all stages of mRNA development, manufacturing, and commercialization. With new sites in Darmstadt and Hamburg, Merck’s recent expansion is expected to aid the U.S. market with pre-clinical as well as commercial offerings. 
•    In February 2022, OriGen received CE Mark and globally launched CryoStore FLEX Freezing Bag. 
 

Key Players in the U.S. Biopreservation Market
Azenta US, Inc.
Biomatrica, Inc.
BioLife Solutions Inc.
MVE Biological Solutions
LabVantage Solutions, Inc.
Taylor-Wharton
Thermo Fisher Scientific, Inc.
Panasonic Corporation
X-Therma Inc.
PrincetonCryo
BioCision LLC
Lifeline Scientific Inc.
Merck KGaA
VWR International, LLC

Market Segmentation
Product Outlook 
Equipment
Freezers
Refrigerators
Consumables
Vials
Straws
Microtiter
Bags
Liquid Nitrogen
Media
Pre-formulated
Home-brew
Laboratory Information Management Systems (LIMS)

 Application Outlook 
Regenerative Medicine
Cell Therapy
Gene Therapy
Others
Biobanking
Human Eggs
Human Sperm
 Veterinary IVF
Drug Discovery