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Structural Biology Market
With a compound annual growth rate (CAGR) of XX% from 2024 to 2033, the worldwide structural biology market is projected to reach approximately US$ XX billion by 2033 from its estimated US$ XX billion in 2023. Understanding the complex structure of living things, the spatial organization of atoms and molecules, and the complicated folding patterns of biopolymers are all made possible by structural biology. When it comes to finding new chemical compounds that target particular biomolecules to treat diseases, this expertise is invaluable.
Structural biology uses a wide variety of physicochemical approaches to help gain important insights into the structural properties of biomolecules. Accurate molecular models can be created by combining data from multiple experimental techniques, which drives the structural biology business forward.

Market Overview
Vital role that structural biology plays in understanding the molecular structures of living things, including as proteins, nucleic acids, lipid membranes, and carbohydrates, is fueling the market's explosive rise. By using methods including X-ray crystallography, nuclear magnetic resonance spectroscopy, cryo-electron microscopy, and computer modeling to identify 3D structures at the atomic level, this discipline offers crucial insights into biomolecule function, dynamics, and interactions.
The knowledge gleaned from structural biology research has applications in biotechnology, medicine, and agriculture in addition to its own field. Clarifying biological macromolecules' functions, roles in cellular processes, disease mechanisms, and assisting in drug discovery all depend on our ability to understand their three-dimensional (3D) structures. More than 206,000 biological macromolecule structures have been experimentally established to date thanks to technological breakthroughs that have accelerated the field. High-quality experiments and time-resolved research have been made possible by advancements in instrumentation, automation, and analytical software in addition to availability of high-brilliance synchrotron radiation and X-Ray Free-Electron Laser sources. Time-resolved structural examinations and the analysis of massive systems are made possible by improved signal-to-noise ratios brought forth by new magnet technology.

Regional Stance
For the duration of the forecast period, North America is expected to continue to dominate the structural biology market. Addressing structural problems pertaining to biological molecules is a major area of focus for the Department of Structural Biology research in the United States, especially at universities such as Stanford Medicine. By utilizing sophisticated biophysical techniques like electron and X-ray crystallography, NMR spectroscopy, and computer analysis, scientists are improving our comprehension of intricate biological systems.
The New York Structural Biology Center (NYSBC) is a well-known partnership that aims to supply state-of-the-art structural biology resources. Its main building, in Harlem, is equipped with cutting-edge technology, such as cryoelectron microscopy and nuclear magnetic resonance spectroscopy, to facilitate top-notch research and analysis. With the creation of NYX, a new beamline designed to take advantage of NSLS-2's brightness, NYSBC's collaboration with Brookhaven National Laboratory significantly expands its possibilities.
The structural studies of macromolecules have been transformed by cryo-EM technology, which has benefits over conventional x-ray crystallography techniques. An intentional step to increase the reach of cryo-EM-based research capabilities across the country is represented by the opening of Cryo-EM facilities at eminent universities like the Indian Institutes of Technology in Chennai, Bombay, and Kanpur, as well as the Bose Institute in Kolkata. These centers, known as the SERB National Facility for Cryo-Electron Microscopy, will concentrate on high-priority topics to expedite structural biology research throughout India and establish the area as a center for innovative scientific pursuits.

Report Highlights
By Tools
During the projection period, the market is expected to be led by the SaaS and standalone modeling segment in terms of tool adoption. Offering Platform as a Service (PaaS) and Software as a Service (SaaS) solutions designed for scientific data administration, analysis, and collaboration, e-SC is a major participant in this market. Notably, e-SC's platform is incredibly flexible and can be deployed on public and private clouds, including Amazon AWS and Microsoft Windows Azure, as well as private ones like Eucalyptus, guaranteeing users' flexibility and accessibility.
SaaS program from e-SC makes scientific workflows more efficient by enabling scientists to upload, edit, and perform activities directly from a web browser. Researchers may collaborate and share data more easily thanks to this cloud-based method, which boosts output and efficiency. The platform from e-SC is backed by a scalable cloud architecture and consists of an extensive set of parts that have been carefully crafted to satisfy the various demands of scientists. Furthermore, the platform is developer-friendly, making it simple to integrate unique analysis services and increasing its usefulness and functionality for consumers.
. Conventional methods have used standalone model deployment, usually with Jupyter notebooks and command line interfaces. These models lacked real-time interaction with software programs or data sources and were frequently simpler in form. Data scientists were typically restricted to particular business units or functional groups, and their role was to supervise the whole model development lifecycle, from design and scoping to deployment and maintenance.
For businesses to verify the efficacy of AI/ML models and manage the obstacles of wider adoption, this transitional stage has proven essential. Organizations may unlock improved collaboration, scalability, and efficiency in their scientific activities by adopting cloud-based SaaS solutions like e-SC, spurring innovation and market growth.

By Application
Drug development and drug discovery are just two of the applications that make up the global structural biology industry. The translation of structural data into useful chemical knowledge is made possible by integrative structural biology, which in turn speeds up the supply of medications to clinical trials. Since a large percentage of pharmacological targets are proteins and nucleic acids and their complexes, it is critical to comprehend their structural properties.
The identification, creation, and optimization of drug-lead compounds are contingent upon a thorough comprehension of the atomic interactions that exist between the target biomolecules and the small-molecule ligands under research. Drug development efforts can be greatly accelerated by the field of structural biology, especially in the area of 3D protein structure elucidation. Recent developments in analytics, robotics, and genome sequencing have completely changed the field and identified a large number of new protein targets.
Lead optimization, target identification, and lead discovery processes have all benefited from the study of these targets and the guidance provided by structural biology tools like NMR spectroscopy and X-ray crystallography. Researchers now have much more power thanks to the development of high-throughput techniques for determining structure, which provide effective screening strategies. Macromolecular X-ray crystallography has long been the go-to technique for structure-based lead drug discovery (SBLDD) among these methods. Cryo-EM, on the other hand, has shown promise as a tool for structural biologists, giving them better ability to visualize intricate biomolecular structures. Therefore, it is anticipated that the pharmaceutical industry's use of structural biology approaches in drug development and discovery workflows will spur innovation and hasten the creation of new treatments.

Market Dynamics
Driver
Structural Biology Through Enhanced Research Quality for Disease Treatment
Improving the caliber of structural biology research is essential to finding cures for conditions like diabetes, Alzheimer's disease, and cancer. There is a rising need for intensive R&D activities due to the problems of drug resistance and high drug attrition rates. It is expected that the use of structural biology and molecular modeling approaches in the drug discovery and development process would increase as a result of this spike in research activity. The development of medications with increased potency can be accelerated by utilizing these cutting-edge techniques, which will accelerate the structural biology market's growth.

Restraints
Challenges in Biological Machines
Intricacies of unraveling how biological machines function pose significant challenges in modern Biology. These machines consist of intricate networks of competing interactions that dynamically form and disassemble over time. Of increasing concern is the impact of post-translational modifications on protein structure and interaction modulation. The evolution of increased complexity in essential molecular machines often occurs through simple, high-probability evolutionary processes, without the apparent emergence of novel functions. Such findings suggest a plausible mechanism for the evolution of complexity in other multi-paralogue protein complexes, thereby presenting constraints on the growth of the structural biology market.

Opportunities
Structural Biology through Multidisciplinary Advancements
Drawing from disciplines such as developmental, systems, and cell biology, as well as physics, information theory, computational sciences, and complex systems science, structural biology is well-positioned to benefit from multidisciplinary ideas. Advances in technology, especially those spearheaded by consortiums for structural genomics, have pushed the field ahead in its quest to determine the three-dimensional structure of each and every protein in a genome. A "resolution revolution" in cryo-EM has occurred in the last ten years due to advances in instruments and software, which have allowed for studies with resolutions comparable to X-ray crystallography as well as investigations into whole cells. Thanks to these methodological advances, structural biology is now a multimodal and multidimensional approach that integrates several methodologies in a synergistic way. The structural biology market has a lot of room to develop and innovate given this progression.

Recent Developments

In August 2022, Constructive Bio launched with a $15m seed investment to re-engineer biology, creating new classes of enzymes, pharmaceuticals, and biomaterials
In April 2023, Bruker advanced its NMR Magnet Portfolio and innovated in industrial solutions
•    In July 2022, Cadence expanded into molecular simulation with the acquisition of OpenEye Scientific, a pioneering leader in computational molecular design
•    In May 2023, Recursion entered into agreements to acquire Cyclica and Valence to bolster chemistry and generative AI capabilities
•    In January 2022, Schrödinger announced the acquisition of XTAL BioStructures, Inc.
•    In November 2023, Ashoka University partnered with Carl Zeiss India to establish a state-of-the-art 'Core Imaging Facility'
•    In November 2022, Biocon Biologics completed the acquisition of Viatris’ Global Biosimilars Business

Key Players in the Structural Biology Market
•    BiosolveIT GmbH
•    Thermo Fisher Scientific Inc.
•    Dassault Systemes
•    Optibrium Ltd.
•    Schrodinger
•    OpenEye Scientific Software, Inc.
•    Chemical Computing Group
•    Certara, L.P.
•    Cresset BioMolecular Discovery Ltd.
•    Acellera Ltd.
•    CGV S.A.
•    Simulations Plus, Inc.

Market Segmentation
By Tools
SaaS and Standalone Modeling
Visualization and Analysis
Others
By Application
Drug Development
Drug Discovery
Others

By Geography
North America
U.S.
Canada
Europe
Germany
France
United Kingdom
Rest of Europe
Asia Pacific
China
Japan
India
Southeast Asia
Rest of Asia Pacific
Latin America
Brazil
Rest of Latin America
Middle East & Africa (MEA)
GCC
North Africa
South Africa
Rest of Middle East & Africa

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Structural Biology Market

Report ID : 623

Category : Biotechnology

No Of Pages : 130

Published on: August 2024

Status: Published

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