Ultra Market Research | Allogeneic Cell Therapy Devices Market
Cutting-edge Allogeneic Cell Therapy Devices Market insights and trends.

Allogeneic Cell Therapy Devices Market

  • Report ID : 590

  • Category : Medical-Devices

  • No Of Pages : 130

  • Published on: July 2024

  • Status: Published

  • Format : Power Point PDF Excel Word

Key Question Answer

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Global Market Outlook

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In-depth analysis of global and regional trends

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Analyze and identify the major players in the market, their market share, key developments, etc.

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To understand the capability of the major players based on products offered, financials, and strategies.

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Identify disrupting products, companies, and trends.

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To identify opportunities in the market.

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Analyze the regional penetration of players, products, and services in the market.

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Comparison of major players financial performance.

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Evaluate strategies adopted by major players.

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Recommendations

Allogeneic Cell Therapy Devices Market


Market for allogeneic cell treatment devices was estimated to be worth US$ XX billion in 2023 and is projected to increase to approximately US$ XX billion by 2033, with a compound annual growth rate (CAGR) of XX% from 2024 to 2033. The market for allogeneic cell therapy is expanding due to the introduction of allogeneic stem cell transplantation (Allo-SCT) as a vital treatment for haematologic malignancies such as acute lymphocytic leukaemia and myelodysplastic syndrome. The market is expected to witness significant increase in Allo-SCT due to its growing clinical usage, technological improvements, and regulatory frameworks that are supportive.


Market Overview
Innovative notion of allogeneic cell therapy in biology is driving the market's quick expansion over the forecast period. Immunologic orthodoxy in the past stipulated that any foreign tissue would cause an immune response, requiring severe immunosuppression during transplant operations. But the development of cell-based therapy has shown that some cell types, most notably mesenchymal stem cells (MSCs), may successfully suppress or escape the immune system. This discovery makes it possible to use allografts without concurrent immunosuppression.
A mainstay of this profession, allogeneic stem cell transplants entail the transfer of healthy blood-forming stem cells from a donor to a recipient, usually for the treatment of immune system diseases and blood malignancies. Allogeneic cell therapies obtain donor cells from members of the same species, in contrast to xenogeneic therapies, which use cells from other species. In order to treat several patients, these therapies entail the growth and possible alteration of cells from healthy donors. Tight human donor screening and Good Manufacturing Practice (GMP) biosafety testing are essential to the market's success because they guarantee the efficacy and safety of allogeneic cell therapies. Growth in the market will spur more innovation and uptake as cell processing technology and regulatory frameworks evolve, securing allogeneic cell therapy's standing as a revolutionary approach in medical treatment.
·    In March 2024, Getinge and CellRev unveiled a platform with the potential to revolutionize allogeneic cell therapy manufacturing. This collaboration aimed to streamline processes and enhance efficiency in the production of cell therapies. Source: https://www.getinge.com/int/company/news/press-releases/2024/4781533-Getinge-and-CellRev-launch-platform-with-potential-to/

·    In October 2022, Allogene Therapeutics introduced CAR T Together, a pioneering initiative in collaboration with leading oncologists nationwide. This initiative focused on expediting the development and recruitment of clinical trials for "off-the-shelf" allogeneic cell therapy investigational products.

 

Key Insights
•    North America dominated the global market with the highest market share.
•    Asia-Pacific is expected to expand at the fastest CAGR during the forecast period.
•    By Therapy Type, the stem cell therapy segment type has held the largest revenue share.
•    By Therapy Type, the non-stem cell therapy type segment is expected to expand at the fastest CAGR during the projected period.
•    By Therapeutic Area, the hematological disorders segment is estimated to hold the highest market share.
•    By Therapeutic Area, the dermatological disorderssegment is anticipated to grow at the fastest CAGR over the projected period.


Regional Stance
In the market for allogeneic cell treatment devices, North America has emerged as the leader in terms of revenue creation. Many things contribute to this domination, one of which is the strong infrastructure that fosters advancements in the field of gene and cell therapy research and development. The American Society of Gene & Cell Therapy (ASGCT), the leading professional membership association for specialists in this field, is essential to progress. Its varied membership, which includes doctors, scientists, patient advocates, and business people, represents the range of specialisations influencing the region's leadership in innovative cell treatment.
Organisations that promote favourable regulatory frameworks and public awareness, such as Americans for Medical Progress (AMP), help to create an atmosphere that is favourable to medical advancements. Their initiatives support those of organisations such as Health Canada, which oversees cell therapy products to guarantee their effectiveness and safety. Cell therapy products fall within the purview of Health Canada as pharmaceuticals, underscoring the strict regulatory supervision that surrounds their development and commercialisation.
•    In October 2022, Century Therapeutics and Bristol Myers Squibb initiated a strategic collaboration to develop iPSC-derived allogeneic cell therapies. This partnership aimed to leverage their respective expertise in advancing innovative cell therapies for various diseases. 
•    In August 2023, Astellas and Poseida Therapeutics announced a strategic investment to bolster Poseida's efforts in redefining cancer cell therapy. This investment aimed to accelerate the development and commercialization of innovative cancer therapies. 
•    In January 2022, Fujifilm expanded its Advanced Therapies CDMO business by acquiring a dedicated cell therapy manufacturing facility from Atara Biotherapeutics, Inc. This acquisition strengthened Fujifilm's capabilities in providing comprehensive cell therapy manufacturing services. 
Due to the region's thriving healthcare industry and innovative atmosphere, Asia-Pacific is anticipated to have the fastest growth in the allogeneic cell therapy devices market. The Asia-Pacific (APAC) area is becoming a hub for international medical device businesses looking for expansion prospects, as it is home to seven of the ten most populous countries worldwide. This change highlights the enormous potential that the APAC region, with its varied population and changing healthcare environment, possesses. In the Asia-Pacific area, there is a noticeable increase in the need for healthcare services, and medical devices are essential to supplying this expanding demand. The sector is experiencing substantial expansion because to factors like rising income levels, increased investments from the private sector, and government incentives. These factors highlight the region's appeal as a major market for allogeneic cell treatment devices, as businesses take advantage of the growing healthcare infrastructure and consumer demand to spur innovation and market share growth.

Report Highlights     
By Therapy Type         
Type of stem cell therapy has become the primary source of revenue in the allogeneic cell therapy devices industry. Because allogeneic stem cell therapy is derived from young, healthy donors, it avoids potential difficulties associated with disease states. This is one of the main advantages it has over autologous stem cell therapy. Because these stem cells are grown and kept in stem cell banks, they are always ready to be used. The ability of allogeneic stem cell therapies to treat a variety of unmet medical conditions, from acute myocardial infarction to dry eye-related macular degeneration, is one of its main advantages. Allogeneic stem cell therapies have great potential for scalability because they can be produced on a massive scale and obtained from universal donors, which makes them ideal for treating huge patient populations.
Non-stem cell treatment type in the allogeneic cell therapy devices market is expected to grow at a notably high cumulative annual growth rate (CAGR) throughout the forecast period. Non-stem cell therapies are a broad class of medical interventions that use human somatic cells that have been separated, grown, and given to patients for either therapeutic or diagnostic uses. These treatments perform a variety of tasks, including providing growth factors, cytokines, and enzymes in vivo. Non-stem cell therapies are used in metabolic disorders, adoptive cell therapy (ACT) for cancer treatment, and as scaffolding cells for open wound injuries such as lesions or burns. Depending on the particular cell type, where it is located, and what it will be used for, different propagation and isolation techniques are used. These treatments fall into two general categories: immunological and non-immune cell types, each of which has a specific therapeutic function.
 

By Therapeutic Area
Haematological disorders category is expected to hold the greatest market share and be the dominant player in the allogeneic cell therapy devices market. The therapeutic effectiveness of allogeneic stem cell transplantation (Allo-SCT) in treating a range of haematological diseases emphasises the significance of this market. Treatment for individuals with Sezary syndrome, myelodysplastic syndrome, acute myeloid leukaemia, and cutaneous T cell lymphoma using allo-SCT exhibits great promise. Furthermore, it is considered an essential course of treatment for patients with acute lymphocytic leukaemia, especially those whose Philadelphia chromosome test results are positive. The haematological diseases sector is expected to dominate because there is a critical need for effective therapeutic approaches in this field and because allogeneic cell therapy is becoming recognised as a possible treatment for these unmet medical requirements. As research and development efforts continue to advance in this field, the hematological disorders segment is poised to remain a key driver of growth within the allogeneic cell therapy devices market, offering hope to patients and healthcare providers alike.
·    In December 2023, both autologous and allogeneic approaches were recognized as viable options in the rapidly expanding cell therapy market. This acknowledgment underscored the diversity and potential of cell therapy treatments. 

Over the estimated period, the dermatological diseases sector of the allogeneic cell treatment devices market is expected to develop at the fastest rate. With notable breakthroughs in the isolation and in vitro proliferation of keratinocyte stem cells, dermatology has become a leading field in stem cell biology and therapy. This advancement has made it easier to quickly translate into the treatment of burns and wounds, which has filled a vital need in dermatological care. The limitations of wound covering by epidermal cells alone have been made clear by the use of allogeneic cell therapy devices in dermatological conditions. This realisation emphasises how crucial it is to use cutting-edge therapy strategies to promote wound healing and improve patient outcomes for dermatology patients. As research in dermatology continues to spur innovation Therefore, the market for allogeneic cell therapy devices is expected to witness exponential growth in this category..

Market Dynamics
Driver
Increased Demand for Healthy Allogeneic Donors and Advancements in Regenerative Medicine
Need for healthy allogeneic donors has increased due to the increasing development of allogeneic cell treatments. Organisations are forming alliances with seasoned parties skilled in allogeneic donor recruitment as well as collections to effectively address this need. This cooperative strategy guarantees a steady supply of donor material, which is necessary for the market for allogeneic cell therapy devices to continue expanding. The increasing prevalence of degenerative and chronic diseases, which place a heavy financial burden on healthcare providers, is driving the need for items pertaining to regenerative medicine. Concurrently, this need is being further heightened by developments in cutting-edge technologies such as nanotechnology, bioengineering, and stem cell therapy. These technical advancements are transforming the therapeutic environment and propelling the use of allogeneic cell therapy devices as essential elements of regenerative medicine solutions.
·    In October 2023, the allogeneic CAR cell therapy market experienced a surge following advancements in gene editing and intellectual property trends. These developments marked a significant milestone in the progression of allogeneic cell therapy. 


Risk of Graft-versus-Host Disease (GVHD)

Market's growth is severely constrained by the inherent risk of graft-versus-host disease (GVHD) connected to tissue transplants or allogeneic cell therapies. The consequences of GVHD, which are frequently brought on by donor T cells that do not match the recipient's HLA, can be fatal. As a result, medical professionals are actively looking for strategies to reduce the risk of GVHD without sacrificing the effectiveness of treatment. The market for allogeneic cell therapy devices is being hindered by the pursuit of innovative gene editing methods, targeted T cell subset therapies, and biochemical pathway disruptions to treat GVHD, as these approaches present obstacles to regulatory approval, clinical implementation, and cost-effectiveness.

Advancements in Allogeneic Cell Cancer Immunotherapy 
Market for allogeneic cell therapy devices has a lot of potential due to the ongoing innovation in allogeneic cell cancer immunotherapy. The possibility of "off-the-shelf" therapy is provided by advancements towards clinical use, such as the banking of third-party T-iPSCs (induced pluripotent stem cells) or the creation of hypoimmunogenic iPSCs via HLA editing. This strategy makes use of banked cells as an endless supply of therapeutic T cells, allowing for cost-effective and expedient application. The application of T-iPSC technology to T cell therapy has the potential to transform cancer treatment and improve clinical outcomes. Additionally, the addition of the iC9 system improves safety and efficacy of iPSC-derived cell therapy by acting as an effective safeguard. These developments herald a new and exciting age for allogeneic immunotherapy in the treatment of cancer and offer significant growth prospects for the market for allogeneic cell therapy devices. These cutting-edge methods have the potential to greatly grow the market and meet unmet requirements in cancer therapy as they move closer to mainstream clinical acceptance.
·    In August 2023, Astellas and Poseida Therapeutics announced a strategic investment to bolster Poseida's efforts in redefining cancer cell therapy. This investment aimed to accelerate the development and commercialization of innovative cancer therapies. Source: https://www.astellas.com/en/news/28271
·    In August 2023, Precision BioSciences completed a strategic transaction with Imugene for Azer-Cel in cancer treatment. This transaction aimed to enhance Precision BioSciences' capabilities in developing novel cancer therapies.


Recent Developments
·    In January 2024, MaxCyte and Wugen entered into a strategic platform license agreement to expedite the scale-up of clinical and commercial manufacturing of Wugen's investigational allogeneic cell therapies for cancers. This collaboration aimed to accelerate the development and availability of innovative cancer treatments. 
·    In June 2022, Immatics and Bristol Myers Squibb expanded their strategic alliance to develop gamma delta allogeneic cell therapy programs. This collaboration aimed to leverage both companies' expertise to advance novel cell therapies for various diseases. 
·    In May 2023, Precision BioSciences provided an update on its allogeneic CAR T programs and the regulatory path forward. This update highlighted the company's progress in advancing novel CAR T cell therapies for cancer treatment. 
·    In October 2023, eXmoor Pharma expanded into a full-service cell and gene therapy CDMO partner with the opening of GMP facilities. This expansion aimed to meet the growing demand for cell and gene therapy manufacturing services. 

·    Key Players in the Allogeneic cell therapy devices Market
·    SSM Cardinal Glennon Children's Medical Center
·    Cleveland Cord Blood Center
·    Duke University School of Medicine
·    New York Blood Center
·    Clinimmune Labs, University of Colorado Cord Blood Bank
·    MD Anderson Cord Blood Bank
·    LifeSouth Community Blood Centers, Inc.
·    Bloodworks Northwest
·    JCR Pharmaceuticals Co., Ltd.
·    Sumitomo Pharma Co., Ltd.
·    Atara Biotherapeutics
·    Mallinckrodt Pharmaceuticals
·    Tego Science Inc
·    Takeda Pharmaceutical Company Limited
·    STEMPEUTICS RESEARCH PVT LTD
·    Biosolution Co., Ltd.
·    MEDIPOST Co., Ltd.
·    

Market Segmentation
By Therapy Type
Stem Cell Therapies
Non-stem Cell Therapies

By Therapeutic Area
Hematological Disorders
Dermatological Disorders
 Others

By Geography
North America
U.S.
Canada
Europe
Germany
France
United Kingdom
Rest of Europe
 Asia Pacific
China
 Japan
India
Southeast Asia
Rest of Asia Pacific
Latin America
Brazil
Rest of Latin America
Middle East & Africa (MEA)
 GCC
North Africa
South Africa
Rest of Middle East & Africa

 

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