Ultra Market Research | United States Hypoparathyroidism Market
United States Hypoparathyroidism Market
Report ID : 999
Category : Pharmaceuticals,United-States(US)
No Of Pages : 94
Published on: February 2025
Status: Published
Format :
Key Question Answer
Global Market Outlook
In-depth analysis of global and regional trends
Analyze and identify the major players in the market, their market share, key developments, etc.
To understand the capability of the major players based on products offered, financials, and strategies.
Identify disrupting products, companies, and trends.
To identify opportunities in the market.
Analyze the regional penetration of players, products, and services in the market.
Comparison of major players financial performance.
Evaluate strategies adopted by major players.
Recommendations
United States Hypoparathyroidism Market Introduction Hypoparathyroidism is a rare endocrine disorder characterized by inadequate secretion of parathyroid hormone (PTH), leading to hypocalcemia and hyperphosphatemia. The condition affects approximately 70,000 to 90,000 individuals in the United States. Historically, treatment has been limited to calcium and vitamin D supplements; however, recent advancements, such as the FDA approval of Ascendis Pharma’s Yorvipath in August 2024, have transformed disease management. United States Hypoparathyroidism Market was valued at USD 200 million in 2022 and is expected to grow significantly due to increased disease awareness, improved diagnostic rates, and novel therapeutics entering the market. The rising prevalence of hypoparathyroidism, largely due to thyroid and neck surgeries, has contributed to market expansion. Furthermore, ongoing research into gene therapy and long-acting PTH analogs is expected to create lucrative opportunities.
Segmentation By Treatment Type • Parathyroid Hormone Replacement Therapy o Recombinant PTH Full-length PTH (1-84) N-terminal PTH (1-34) Others o Synthetic Analogues Modified PTH peptides Long-acting PTH analogues o Others • Vitamin D Analogues o Calcitriol Oral formulations Injectable formulations Others o Alfacalcidol Capsules Drops o Others • Calcium Supplements o Calcium Carbonate Tablets Chewables Others o Calcium Citrate Capsules Powders o Others
By Route of Administration • Oral o Tablets Immediate-release Extended-release Others o Capsules Gelatin-based Vegetarian o Others • Parenteral o Subcutaneous Injections Prefilled syringes Vials o Intravenous Infusions Single-dose Multi-dose o Others
By Distribution Channel • Hospital Pharmacies o Inpatient Pharmacies Acute care hospitals Specialty hospitals o Outpatient Pharmacies Hospital-affiliated clinics Ambulatory care centers o Others • Retail Pharmacies o Chain Pharmacies National chains Regional chains o Independent Pharmacies Community pharmacies Compounding pharmacies o Others • Online Pharmacies o Mail-order Pharmacies Subscription-based services On-demand delivery o Telepharmacy Services Virtual consultations E-prescriptions o Others
List of Market Players 1. Ascendis Pharma (Denmark) 2. Takeda Pharmaceutical Company (Japan) 3. Amolyt Pharma (France) 4. BridgeBio Pharma (USA) 5. Calcilytix Therapeutics (USA) 6. EnteraBio Ltd. (Israel) 7. Shire Pharmaceuticals (USA) 8. Roche Holding AG (Switzerland) 9. Eli Lilly and Company (USA) 10. Pfizer Inc. (USA) 11. Novartis International AG (Switzerland) 12. AbbVie Inc. (USA) 13. Sanofi S.A. (France) 14. GlaxoSmithKline plc (UK) 15. Amgen Inc. (USA)
Drivers United States Hypoparathyroidism Market is primarily driven by the approval of innovative therapies like Ascendis Pharma’s Yorvipath (FDA-approved in August 2024), offering a breakthrough in disease management. The increasing prevalence of hypoparathyroidism, often caused by thyroid or neck surgeries, has significantly expanded the patient base. Rising awareness and improved diagnostic capabilities have facilitated earlier detection, leading to higher treatment rates. The growth of biopharmaceutical companies focusing on PTH replacement therapy, gene therapy, and regenerative medicine has further accelerated market expansion. Additionally, government incentives and regulatory support for orphan diseases encourage research and development (R&D) in this field. The increasing availability of digital health solutions aids in patient monitoring, adherence, and disease management, further supporting market growth.
Restraints Despite rapid advancements, high treatment costs remain a significant challenge in the United States Hypoparathyroidism Market. Novel therapies like Yorvipath may not be accessible to all patients due to insurance coverage limitations and reimbursement challenges. The complex regulatory approval process further slows the entry of new drugs into the market. Another major challenge is the limited awareness among healthcare providers, leading to misdiagnosis or delayed diagnosis in some cases. Conducting large-scale clinical trials for hypoparathyroidism remains difficult due to the rare nature of the disease. Additionally, concerns over long-term safety profiles of newly introduced treatments may hinder physician and patient adoption.
Opportunities United States Hypoparathyroidism Market presents several growth opportunities, including advancements in biotechnology and targeted drug therapies. Companies are investing in gene therapy and regenerative medicine, aiming to develop curative treatments rather than lifelong management strategies. The adoption of digital health platforms for remote patient monitoring and medication adherence is also creating new revenue streams. Increased research funding and orphan drug incentives provide pharmaceutical companies with opportunities to expand their R&D pipelines. Collaborations between biotech firms, research institutions, and government organizations could lead to the discovery of more effective, long-lasting treatments.
Trends United States Hypoparathyroidism Market is also seeing the move towards personalized medicine, where biologic and peptide-based medicines are customized for specific patient needs. The innovation in long-acting PTH analogs has enhanced convenience and compliance with treatments. Another key trend is increased investment in gene therapy, with companies exploring genetic modification techniques to provide potential cures. The expansion of telemedicine and e-pharmacies is also making treatment more accessible, particularly for patients in remote areas. Additionally, the integration of AI in drug discovery is accelerating the identification of novel drug candidates and optimizing treatment protocols. Pharmaceutical companies are also focusing on partnerships with healthcare providers to improve patient education and adherence.
Key Target Audience • Pharmaceutical Companies • Healthcare Providers • Regulatory Authorities • Research Institutions • Investors and Venture Capitalists • Medical Device Manufacturers
Frequently Asked Questions (FAQ's)
The market was valued at approximately USD 200 million in 2022 and is expected to grow significantly.
Key drivers include the approval of novel therapies, increased disease awareness, and advancements in biotechnology.
Challenges include high treatment costs, regulatory hurdles, and limited awareness among healthcare providers.
Major players include Ascendis Pharma, Takeda Pharmaceuticals, Amolyt Pharma, and BridgeBio Pharma.
Trends include personalized medicine, long-acting PTH analogs, gene therapy, and AI-driven drug discovery.
1. Introduction 1.1 Report Description 1.2 Research Methodology 1.2.1 Data Mining 1.2.2 Market Modeling and Forecasting 1.2.3 Data Validation 1.2.4 Industry Analysis
2. Market Dashboard
3. Market Overview 3.1 Market Definition and Scope 3.2 Market Segmentation 3.2.1 By Treatment Types • Parathyroid Hormone Replacement Therapy o Recombinant PTH Full-length PTH (1-84) N-terminal PTH (1-34) Others o Synthetic Analogues Modified PTH peptides Long-acting PTH analogues o Others • Vitamin D Analogues o Calcitriol Oral formulations Injectable formulations Others o Alfacalcidol Capsules Drops o Others • Calcium Supplements o Calcium Carbonate Tablets Chewables Others o Calcium Citrate Capsules Powders o Others 3.2.2 By Patient Demographics • Pediatric Patients o Infants o Toddlers and Young Children • Adult Patients o Young Adults o Geriatric Population 3.2.3 By Distribution Channels • Hospital Pharmacies o Inpatient Pharmacies Acute care hospitals Specialty hospitals o Outpatient Pharmacies Hospital-affiliated clinics Ambulatory care centers o Others • Retail Pharmacies o Chain Pharmacies National chains Regional chains o Independent Pharmacies Community pharmacies Compounding pharmacies o Others • Online Pharmacies o Mail-order Pharmacies Subscription-based services On-demand delivery o Telepharmacy Services Virtual consultations E-prescriptions o Others 3.2.4 By Therapeutic Applications • First-Line Treatment o Calcium & Vitamin D Supplements o PTH Replacement Therapy • Refractory or Chronic Hypoparathyroidism o Long-acting PTH Therapy o Experimental Treatments 3.3 Market Dynamics 3.3.1 Drivers 3.3.2 Restraints 3.3.3 Opportunities 3.3.4 Challenges
4. United States Hypoparathyroidism Market by Treatment Types 4.1 Introduction 4.2 Market Size and Growth Rate by Treatment Types (2024-2030) 4.2.1 Parathyroid Hormone Replacement Therapy • Recombinant PTH • Synthetic Analogues 4.2.2 Vitamin D Analogues • Calcitriol • Alfacalcidol 4.2.3 Calcium Supplements • Calcium Carbonate • Calcium Citrate
5. United States Hypoparathyroidism Market by Patient Demographics 5.1 Introduction 5.2 Market Size and Growth Rate by Patient Demographics (2024-2030) 5.2.1 Pediatric Patients • Infants • Toddlers and Young Children 5.2.2 Adult Patients • Young Adults • Geriatric Population
6. United States Hypoparathyroidism Market by Distribution Channels 6.1 Introduction 6.2 Market Size and Growth Rate by Distribution Channels (2024-2030) 6.2.1 Hospital Pharmacies • Inpatient Pharmacies • Outpatient Pharmacies 6.2.2 Retail Pharmacies • Chain Pharmacies • Independent Pharmacies 6.2.3 Online Pharmacies
7. United States Hypoparathyroidism Market by Therapeutic Applications 7.1 Introduction 7.2 Market Size and Growth Rate by Therapeutic Applications (2024-2030) 7.2.1 First-Line Treatment • Calcium & Vitamin D Supplements • PTH Replacement Therapy 7.2.2 Refractory or Chronic Hypoparathyroidism • Long-acting PTH Therapy • Experimental Treatments
8. Competitive Landscape 8.1 Company Profiles 8.1.1 Ascendis Pharma (Denmark) • Business Overview • Product Portfolio • Strategic Developments • Financial Overview 8.1.2 Takeda Pharmaceutical Company (Japan) 8.1.3 Amolyt Pharma (France) 8.1.4 BridgeBio Pharma (United States) 8.1.5 Calcilytix Therapeutics (United States) 8.1.6 EnteraBio Ltd. (Israel) 8.1.7 Roche Holding AG (Switzerland) 8.1.8 Eli Lilly and Company (United States) 8.1.9 Pfizer Inc. (United States) 8.1.10 Novartis International AG (Switzerland) 8.1.11 AbbVie Inc. (United States) 8.1.12 Sanofi S.A. (France) 8.1.13 GlaxoSmithKline plc (United Kingdom) 8.1.14 Amgen Inc. (United States)
9. Conclusion and Recommendations
10. Appendix 10.1 List of Tables 1. United States Hypoparathyroidism Market, 2024-2030 (USD Million) 2. Market Segmentation by Treatment Type, 2024-2030 (USD Million) 3. Market Segmentation by Patient Demographics, 2024-2030 (USD Million) 4. Market Segmentation by Distribution Channel, 2024-2030 (USD Million) 5. Competitive Landscape – Market Share by Key Players, 2024
10.2 List of Figures 1. Market Growth Forecast (2024-2030) 2. Market Share by Treatment Type 3. Market Share by Patient Demographics 4. Market Share by Distribution Channel 5. Competitive Landscape – Revenue Comparison
Research Methodology
The process of market research at Ultra Market Research is an iterative in application and usually follows following path. Information from secondary used to build data models, then results from data models are validated from primary participants. Then cycle repeats where, according to inputs from primary participants, additional secondary research is done, and new Information is again incorporated into data model. The process continues till desired level of Information is not generated
To calculate the market size, the report considers the revenue generated from the sales of Ultra Market Research providers. The revenue generated from the sales of Ultra Market Research has been calculated through primary and secondary research. The report also presents the key players operating in the Ultra Market Research market across the globe identified through secondary research and a corresponding detailed analysis of the top vendors in the market. The market size calculation also includes distribution channel segmentation determined using secondary sources and verified through primary sources.
Secondary Research
The secondary research source that are typically referred to include, but are not limited to:
Company websites, annual reports, financial reports, broker reports, investor presentations and SEC filings
Internal and external proprietary databases, relevant patent and regulatory databases
National government documents, statistical databases and market reports
News articles, press releases and web-casts specific to the companies operating in the market
The source for secondary research includes but is not limited to: Factiva, Hoovers and Statista
Inner Circle Represents – Stage of Research Process
Middle Circle Represents – Source of Information
Outer Circle Represents – Information Derived from that source
Primary Research We conduct primary interviews on an ongoing basis with industry participants and commentators in order to validate data and analysis. A typical research interview fulfills the following functions:
It provides first-hand Information on the market size, market trends, growth trends, competitive landscape, future outlook etc.
Helps in validating and strengthening the secondary research findings
Further develops the analysis team’s expertise and market understanding
Primary research involves E-mail interactions, telephonic interviews as well as face-to-face interviews for each market, category, segment and sub-segment across geographies
The participants who typically take part in such a process include, but are not limited to:
Industry participants: CEOs, VPs, marketing/ distribution channel managers, market intelligence managers and national sales managers
Purchasing managers, technical personnel, distributors and resellers
Outside experts: Investment bankers, valuation experts, research analysts specializing in specific markets
Key opinion leaders specializing in different areas corresponding to different industry distribution channels
Models Where no hard data is available, we use modeling and estimates in order to produce comprehensive data sets. A rigorous methodology is adopted in which the available hard data is cross referenced with the following data distribution channels to produce estimates:
Demographic data: Population split by segment
Macro-economic indicators: GDP, etc.
Industry indicators: Expenditure, distribution channel stage & infrastructure, sector growth and facilities.
Data is then cross checked by the expert panel.
2..1 Company Share Analysis Model
Company share analysis is used to derive the size of United States market. As well as study of revenues of companies for last three to five years also provide the base for forecasting the market size and its growth rate. This model is built in following steps: 2..2 Revenue Based Modeling
Revenue based models can be built in two ways – Top-Down or Bottom-Up irrespective of industry. Market size estimated from company share analysis acts as a validation point for bottom-up approach where as it acts as starting point for top-down approach.
2.1 Research Limitations Inflation is not a part of pricing in this report. Prices of United States Hypoparathyroidism Market and its derivatives vary in each region and hence similar revenue ratio does not follow for each individual region. The same price for each distribution channel has been taken into account while estimating and forecasting market revenue Globally. Regional average price has been considered while breaking down this market by application in each region. This report provides market size of United States Hypoparathyroidism Market for the past year and forecasts for the next six years. United States Hypoparathyroidism Market size is given in terms of revenue Market revenue is defined in USD Million. Market numbers are given on the basis of different United States Hypoparathyroidism Market categories. Market size and forecasts for each major application is provided in the context of Global market. The numbers provided in this report are derived on the basis of demand for United States Hypoparathyroidism Market from different application industries in different regions.
Segmentation By Treatment Type • Parathyroid Hormone Replacement Therapy o Recombinant PTH Full-length PTH (1-84) N-terminal PTH (1-34) Others o Synthetic Analogues Modified PTH peptides Long-acting PTH analogues o Others • Vitamin D Analogues o Calcitriol Oral formulations Injectable formulations Others o Alfacalcidol Capsules Drops o Others • Calcium Supplements o Calcium Carbonate Tablets Chewables Others o Calcium Citrate Capsules Powders o Others
By Route of Administration • Oral o Tablets Immediate-release Extended-release Others o Capsules Gelatin-based Vegetarian o Others • Parenteral o Subcutaneous Injections Prefilled syringes Vials o Intravenous Infusions Single-dose Multi-dose o Others
By Distribution Channel • Hospital Pharmacies o Inpatient Pharmacies Acute care hospitals Specialty hospitals o Outpatient Pharmacies Hospital-affiliated clinics Ambulatory care centers o Others • Retail Pharmacies o Chain Pharmacies National chains Regional chains o Independent Pharmacies Community pharmacies Compounding pharmacies o Others • Online Pharmacies o Mail-order Pharmacies Subscription-based services On-demand delivery o Telepharmacy Services Virtual consultations E-prescriptions o Others