Ultra Market Research | United States Hypoparathyroidism Market 
United States Hypoparathyroidism Market Overview – Growth Trends, Competitive Landscape, and Forecast (2024-2030)

United States Hypoparathyroidism Market 

  • Report ID : 999

  • Category : Pharmaceuticals,United-States(US)

  • No Of Pages : 94

  • Published on: February 2025

  • Status: Published

  • Format : Power Point PDF Excel Word

Key Question Answer

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Global Market Outlook

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In-depth analysis of global and regional trends

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Analyze and identify the major players in the market, their market share, key developments, etc.

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To understand the capability of the major players based on products offered, financials, and strategies.

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Identify disrupting products, companies, and trends.

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To identify opportunities in the market.

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Analyze the regional penetration of players, products, and services in the market.

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Comparison of major players financial performance.

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Evaluate strategies adopted by major players.

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Recommendations

United States Hypoparathyroidism Market 
Introduction
Hypoparathyroidism is a rare endocrine disorder characterized by inadequate secretion of parathyroid hormone (PTH), leading to hypocalcemia and hyperphosphatemia. The condition affects approximately 70,000 to 90,000 individuals in the United States. Historically, treatment has been limited to calcium and vitamin D supplements; however, recent advancements, such as the FDA approval of Ascendis Pharma’s Yorvipath in August 2024, have transformed disease management. United States Hypoparathyroidism Market was valued at USD 200 million in 2022 and is expected to grow significantly due to increased disease awareness, improved diagnostic rates, and novel therapeutics entering the market. The rising prevalence of hypoparathyroidism, largely due to thyroid and neck surgeries, has contributed to market expansion. Furthermore, ongoing research into gene therapy and long-acting PTH analogs is expected to create lucrative opportunities.

 

Segmentation
By Treatment Type
•    Parathyroid Hormone Replacement Therapy
o    Recombinant PTH
    Full-length PTH (1-84)
    N-terminal PTH (1-34)
    Others
o    Synthetic Analogues
    Modified PTH peptides
    Long-acting PTH analogues
o    Others
•    Vitamin D Analogues
o    Calcitriol
    Oral formulations
    Injectable formulations
    Others
o    Alfacalcidol
    Capsules
    Drops
o    Others
•    Calcium Supplements
o    Calcium Carbonate
    Tablets
    Chewables
    Others
o    Calcium Citrate
    Capsules
    Powders
o    Others
 

By Route of Administration
•    Oral
o    Tablets
    Immediate-release
    Extended-release
    Others
o    Capsules
    Gelatin-based
    Vegetarian
o    Others
•    Parenteral
o    Subcutaneous Injections
    Prefilled syringes
    Vials
o    Intravenous Infusions
    Single-dose
    Multi-dose
o    Others
 

By Distribution Channel
•    Hospital Pharmacies
o    Inpatient Pharmacies
    Acute care hospitals
    Specialty hospitals
o    Outpatient Pharmacies
    Hospital-affiliated clinics
    Ambulatory care centers
o    Others
•    Retail Pharmacies
o    Chain Pharmacies
    National chains
    Regional chains
o    Independent Pharmacies
    Community pharmacies
    Compounding pharmacies
o    Others
•    Online Pharmacies
o    Mail-order Pharmacies
    Subscription-based services
    On-demand delivery
o    Telepharmacy Services
    Virtual consultations
    E-prescriptions
o    Others

 

List of Market Players
1.    Ascendis Pharma (Denmark)
2.    Takeda Pharmaceutical Company (Japan)
3.    Amolyt Pharma (France)
4.    BridgeBio Pharma (USA)
5.    Calcilytix Therapeutics (USA)
6.    EnteraBio Ltd. (Israel)
7.    Shire Pharmaceuticals (USA)
8.    Roche Holding AG (Switzerland)
9.    Eli Lilly and Company (USA)
10.    Pfizer Inc. (USA)
11.    Novartis International AG (Switzerland)
12.    AbbVie Inc. (USA)
13.    Sanofi S.A. (France)
14.    GlaxoSmithKline plc (UK)
15.    Amgen Inc. (USA)

 

Drivers
United States Hypoparathyroidism Market is primarily driven by the approval of innovative therapies like Ascendis Pharma’s Yorvipath (FDA-approved in August 2024), offering a breakthrough in disease management. The increasing prevalence of hypoparathyroidism, often caused by thyroid or neck surgeries, has significantly expanded the patient base.
Rising awareness and improved diagnostic capabilities have facilitated earlier detection, leading to higher treatment rates. The growth of biopharmaceutical companies focusing on PTH replacement therapy, gene therapy, and regenerative medicine has further accelerated market expansion. Additionally, government incentives and regulatory support for orphan diseases encourage research and development (R&D) in this field. The increasing availability of digital health solutions aids in patient monitoring, adherence, and disease management, further supporting market growth.

 

Restraints
Despite rapid advancements, high treatment costs remain a significant challenge in the United States Hypoparathyroidism Market. Novel therapies like Yorvipath may not be accessible to all patients due to insurance coverage limitations and reimbursement challenges. The complex regulatory approval process further slows the entry of new drugs into the market.
Another major challenge is the limited awareness among healthcare providers, leading to misdiagnosis or delayed diagnosis in some cases. Conducting large-scale clinical trials for hypoparathyroidism remains difficult due to the rare nature of the disease. Additionally, concerns over long-term safety profiles of newly introduced treatments may hinder physician and patient adoption.

 

Opportunities
United States Hypoparathyroidism Market presents several growth opportunities, including advancements in biotechnology and targeted drug therapies. Companies are investing in gene therapy and regenerative medicine, aiming to develop curative treatments rather than lifelong management strategies.
The adoption of digital health platforms for remote patient monitoring and medication adherence is also creating new revenue streams. Increased research funding and orphan drug incentives provide pharmaceutical companies with opportunities to expand their R&D pipelines. Collaborations between biotech firms, research institutions, and government organizations could lead to the discovery of more effective, long-lasting treatments.

 

Trends
United States Hypoparathyroidism Market is also seeing the move towards personalized medicine, where biologic and peptide-based medicines are customized for specific patient needs. The innovation in long-acting PTH analogs has enhanced convenience and compliance with treatments.
Another key trend is increased investment in gene therapy, with companies exploring genetic modification techniques to provide potential cures. The expansion of telemedicine and e-pharmacies is also making treatment more accessible, particularly for patients in remote areas.
Additionally, the integration of AI in drug discovery is accelerating the identification of novel drug candidates and optimizing treatment protocols. Pharmaceutical companies are also focusing on partnerships with healthcare providers to improve patient education and adherence.

 

Approved and Pipeline Products
Approved Products
•    Yorvipath (Ascendis Pharma)
•    Natpara (Takeda Pharmaceuticals)
 

Pipeline Products
•    AZP-3601 (Amolyt Pharma)
•    TransCon PTH (Ascendis Pharma)
•    EB612 (Entera Bio)
•    Calcilytix (BridgeBio Pharma)

 

Key Target Audience
•    Pharmaceutical Companies
•    Healthcare Providers
•    Regulatory Authorities
•    Research Institutions
•    Investors and Venture Capitalists
•    Medical Device Manufacturers

 

Frequently Asked Questions (FAQ's)

The market was valued at approximately USD 200 million in 2022 and is expected to grow significantly.
Key drivers include the approval of novel therapies, increased disease awareness, and advancements in biotechnology.
Challenges include high treatment costs, regulatory hurdles, and limited awareness among healthcare providers.
Major players include Ascendis Pharma, Takeda Pharmaceuticals, Amolyt Pharma, and BridgeBio Pharma.
Trends include personalized medicine, long-acting PTH analogs, gene therapy, and AI-driven drug discovery.

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